Maropitant citrate hydrate

Maropitant citrate hydrate is a synthetic compound that has emerged as a significant medication in veterinary medicine, particularly for its antiemetic properties. The discovery of maropitant can be traced back to the early 2000s, when researchers aimed to develop new agents that could effectively combat vomiting and nausea in pets, particularly in dogs and cats. This need arose from the limitations of existing antiemetic medications, which often had insufficient efficacy or undesirable side effects.

The chemical structure of maropitant is derived from a novel class of compounds known as neurokinin-1 (NK1) receptor antagonists. The mechanism of action involves the selective inhibition of the NK1 receptors, which are responsible for mediating the effects of substance P, a neuropeptide that plays a pivotal role in the emetic pathway. By blocking these receptors, maropitant effectively prevents and alleviates vomiting caused by various triggers, including motion sickness, chemotherapy, and other underlying medical conditions.

Brand: Soarwin

CAS No.: 359875-09-5

EC number: 837-630-8

Molecular Formula: C32H40N2O.C6H8O7.H2O

Density: 1.484

Boiling point: 572.6 °C at 760 mmHg

Melting point: 153-159 °C(lit.)